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The Emergence of Life: From Chemical Origins to Synthetic Biology, by Pier Luigi Luisi
Download PDF The Emergence of Life: From Chemical Origins to Synthetic Biology, by Pier Luigi Luisi
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The origin of life from inanimate matter has been the focus of much research for decades, both experimentally and philosophically. Luisi takes the reader through the consecutive stages from prebiotic chemistry to synthetic biology, uniquely combining both approaches. This book presents a systematic course discussing the successive stages of self-organisation, emergence, self-replication, autopoiesis, synthetic compartments and construction of cellular models, in order to demonstrate the spontaneous increase in complexity from inanimate matter to the first cellular life forms. A chapter is dedicated to each of these steps, using a number of synthetic and biological examples. With end-of-chapter review questions to aid reader comprehension, this book will appeal to graduate students and academics researching the origin of life and related areas such as evolutionary biology, biochemistry, molecular biology, biophysics and natural sciences.
- Sales Rank: #907159 in Books
- Brand: Brand: Cambridge University Press
- Published on: 2010-08-26
- Original language: English
- Number of items: 1
- Dimensions: 9.69" h x .71" w x 7.44" l, 1.17 pounds
- Binding: Paperback
- 332 pages
- Used Book in Good Condition
Review
Review of the hardback: 'Charting the successful development of life is certainly a fascinating challenge and one which Luisi addresses head on in this book from both a scientific and philosophical standpoint. ... This comprehensive volume will particularly suit those students and academics who wish to delve further into early natural history, either out of an innate curiosity or a more professional approach to unravel one of the true mysteries of nature.' Chemistry & Industry
Review of the hardback: 'This work is a fresh and exciting new look at a now long-established field. Because it is so fascinating to read, it is a work that I feel deserves to be in every library of science.' Chemistry World
Review of the hardback: '... the reviewer recommends this book for specialists in Earth and life sciences.' Zentralblatt für Geologie und Paläontologie
About the Author
PIER LUIGI LUISI became Professor Emeritus (Macromolecular Chemistry) at ETH-Zurich in 1982, where he was later made Dean; he is currently professor of Biochemistry at the University of Rome3. He has published prolifically on the origins of life and the science of complexity.
Most helpful customer reviews
28 of 29 people found the following review helpful.
Opened questions - no answers
By Rob
The Emergence of Life by Pier Luigi Luisi is a thoughtful book. It is not a book where to find easy answers on how the life appeared on Earth. Rather, on the contrary. The author scholastic and erudition is impressive on subjects from fundamental physics and chemistry up to polictics and language. Luisi included topics as difficult to define as self-organization and emergence, not only in the biological and biochemical context, but also in social behaviour and economics, for example. The text is crystal-clear, based mostly on arguments from others, but also by the author's personal thinkings based on a life long scientific carreer (over 300 scientific publications), first at the ETH-Zurich (Switzerland) then at Rome 3 (Italy). The book is strongly based on scientific support and thoroughly referenced (over 500 scientific references, including papers of scientific journals and books), and includes an excellent subject index. Graphs and figures are of good support to understand the text. I really recommend it for readers interested on the non-trivial hypotheses of life arousal on Earth. A point (?): Luisi does not include any religious discussion in his book. I was very pleased with his well balanced way of thinking.
23 of 24 people found the following review helpful.
The Emergence of Life: From Chemical Origins to Synthetic Biology
By California Star
How could life emerge from unanimate matter? Despite the importance of this question and its broad public interest, the field of research in origin-of-life is relatively undermined in the scientific community. This field doesn't offer a promising carrier for a young scientist, mainly because of its slow development and the fact that it doesn't benefit from recent technical progress, as is the case with other fields,
Therefore, as a result of its small scientific community, contrasted by its large public issue and demand, many books have been published on this topic, a wide range of which present chapters written by the same authors. The results is a great redundancy of information as well as scientific views. If you've read half a dozen books on the origin-of-life and you're looking for something fresher, more vibrant, which presents a new outlook on the subject, then stop looking, this is the book for you!
Pier Luigi Luisi is a chemist who has devoted his scientific carrier to this important question in modern biology. As author of over 400 peer-reviewed publications, he has covered a great deal of various approaches to the origin of life, as well as a multitude of other books on fields directly related to the subject, such as "Giant Vesicles" and "Self-Production of Supramolecular Structures" (also found in Amazon).
Luisi's "The Emergence of Life" is a systematic overview of the field, as seen from an insider. Each part of the big picture, from prebiotic soup to the minimal cell, is thoroughly divided into single chapters and given a critical review, each time carefully pointing out the weakness of our current ideas on the various steps of life evolving from matter. I think even a creationist could greatly benefit from this book as it will give him/her a large variety of arguments to criticize the "non-Intelligent Design approach" to the Origin of Life ;)
Each chapter ends with a few questions for the reader, many of which have a charming balance between philosophy and chemistry put into one sentence. For example, the first question in chapter 5 (which covers the topic of "Self-organization") is:
"Do you accept the idea that self-organization in prebiotic times was the main driving force for the formation of the first living cells? (If not, what would you add to the picture?)"
While his approach leads to more general philosophical problems, Luisi doesn't dodge these topics, rather, he deals with each and every one with great care, as in the case of the importance of the theory of autopoiesis in understanding consciousness (for the author's competance in this field, I would like to mention another book he has recently written: "Mind and Life: Discussions with the Dalai Lama on the Nature of Reality", which just received a positive review in Nature). While most of the book deals with serious chemical problems, philosophical topics are dealt with delicately and in a highly constructed manner, resulting in a book with both a wide range of scientific information as well as an extensive overview of the highly philosophical, ethical nature of this field.
9 of 9 people found the following review helpful.
Synthetic Biology and Autopoiesis
By whiteelephant
In "The Emergence of Life", Pier Luigi Luisi gives an overview of synthetic biology, a field in which he has some 40+ years experience. In a sense this almost reads like a long review article, although Luisi's personal preferences and philosophy are presented most prominently. Luisi defines life on the basis of 'autopoeisis': "a system can be said to be living if it is able to transform external energy into an internal process of self-maintenance and production of its own components." Autopoeisis was a view of life first put forth by Chilean biologists Humberto Maturana and Francisco Varela in the 1970s. A main point of Luisi's account is that this view was regrettably ignored in favor of nucleic acid reductionism. Luisi is optimistic, however, that the current trend towards systems biology is reviving many of the views of the Chilean school. It is worth noting that Varela was heavily involved at the interface of biology and Buddhism, and it appears as though Luisi has been as well - which might be one reason why some biologists are reluctant to embrace the word 'autopoiesis', even if they agree with the fundamental tenets.
Given this perspective, the book is quite critical of reductionist RNA-world accounts of the origin of life. While self-replicating RNA molecules might sound elegant, as Luisi puts it "in fact, we simply do not know how to make long polypeptides by prebiotic means". Luisi is more favorable towards 'compartmentalist' studies of synthetic biology that focus on micelles, liposomes, and vesicles in an attempt to create a 'minimal cell'. Much of the book is an overview of the research that has been done in this regard. It is full of references, and if you are not particularly keen on learning such details you might find it somewhat dry.
One criticism I had of the book is that it is almost too synthetic in perspective. At many times I got the sense that the argument reduced to what is easier in the lab is a better explanation for the origin of life. Personally, I am not all that interested in these early attempts to create proto-life in the laboratory, and am not convinced that they can tell us all that much concerning the enormous parameter space that must have been available during the Earth's history. Basically, I don't feel that I learned all that much about the origin of life, rather than that it is quite difficult and enormously contentious.
A second minor criticism I have of this book is that it doesn't really do a great job in incorporating fields like physics and information theory. To give just one example, Luisi references Schrodinger's famous book 'What is Life?' but doesn't really talk about the negentropy ('free energy') view of life. This is too bad, as it would have provided a natural bridge between the chemistry and the higher level concepts of autopoeisis. In fact, I will note that neuroscientist Karl Friston has been leading a revival of sorts of Schrodinger 'free energy' view, and it has some pretty clear similarities to the autopoeisis account. This book doesn't get into the physics quite enough for my tastes - for example, I found the chapter on emergence a little weak. However, there is no doubting that Luisi's speciality, synthetic biology, is extensively covered.
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